Which of the following statements supports the one gene-one enzyme hypothesis? a) a mutation in a single gene can result in a defective protein. b) alkaptonuria results when individuals lack multiple enzymes involved in the catalysis of homogentisic acid. c) sickle-cell anemia results in normal hemoglobin. d) multiple antibody genes can code for different related proteins, depending on the splicing that takes place post-transcriptionally.

Option A

Explanation:

One gene one enzyme hypothesis was proposed by George Wells Beadle in which he stated that one gene directly affects the production of the  single enzyme.

This consequently affects the individual step in the whole metabolic pathway.  

So, a mutation in the single gene will lead to the production of the faulty protein. The step of the metabolism will be affected in which the faulty enzyme will participate.

the answer is a! (2.9 x 10^-18 j) hope i could someone. : )