The instructions on the tpa vials read to reconstitute with 50 ml of sterile water to make a total of 50 mg/50 ml (1 mg/ml). the hospital protocol is to infuse 0.9 mg/kg over 60 minutes with 10% of the dose given as a bolus over 1 minute. n. t. weighs 143 pounds. what is the amount of the bolus dose, in both milligrams and milliliters, that you will administer in the first minute? what is the amount of the remaining dose that you will need to administer?

1. what is the amount of the bolus dose, in both milligrams and milliliters, that you will administer in the first minute? 
The doses is 0.9 mg/kg and the weight of the patient is 143 pounds. So, the total doses of drug needed will be: 
Total doses= 0.9 mg/kg * 143 pounds * 0.453592 kg/pound= 58.37 mg.

10% of the doses will be given bolus for 1 min, so the amount would be:
Bolus doses= 10%*58.37 mg= 5.837 mg.
In mililiters, it would be: 5.837 mg * 1ml/mg= 5.837 ml.

2. what is the amount of the remaining dose that you will need to administer?
The remaining dose would be 90% of the total dose. You can either calculate it directly or subtract the bolus doses from the total doses.
Remaining doses= total doses- bolus doses= 58.37 mg- 5.837 mg= 52.533mg