Neuroendocrine cells of the hypothalamus release into the bloodstream.

Neuroendocrine cells of the hypothalamus release releasing hormones into the bloodstream.
Releasing or hypothalamic hormones have a stimulatory or inhibitory effect on the release of the pituary hormones. The main hormones are:
·     Gonadotropin-releasing hormone (GnRH) stimulates the pituitary to release gonadotropin.
·     Thyrotropin-releasing hormone (TRH) stimulates the pituitary to release thyrotropin.
·     Growth hormone–releasing hormone (GHRH) stimulates the pituitary to release somatotropin.
·     Corticotropin-releasing hormone (CRH) stimulates the pituitary to release corticotropin.
·     Somatostatin which inhibit the release of somatotropin from pituitary and inhibits the release of some gastrointestinal hormones.