Are genetic defects associated with abnormalities of autosomes or of a sex chromosome

Genetic defects are associated with both abnormal autosomes as well as abnormalities in the gender-based chromosomes. Autosomal abnormalities occur if there is an abnormality on any of the first 22 pairs of chromosomes.  The abnormality is linked to gender if it occurs on the twenty-third chromosomal pair. Both of these abnormalities are due to chromosomal errors or genetic mutation.

Downs Syndrome is a common genetic disorder that causes developmental delays and health problems. This disorder occurs when the person has extra genetic material added to the twenty-first chromosome. 

Humans can affect weathering and erosion in several ways.  humans cause  increases in acid rain and pollution, which increase the amount of  weathering  agents in the air and water, and then on land.for an easy answer: 1) acid rain2) pollution