The nurse is educating a client who will be adding an injection of pramlintide to his insulin regimen. what information is most important for the nurse to share with this client to ensure safe medication administration

Do not give pramlintide in the same site where insulin is administered.

Pramlintide and insulin should be administrated via separate subcutaneous injections. This is because they have different pH and if they are together they can cause precipitation of the insulin or solubilization of crystalline insulin components.