Maoi's were discovered by accident when iproniazid was being used to treat.

MAOI's work better with patients whose depression becomes more acute as the day progresses. An enzyme named monoamine oxidase is intricate in eliminating the serotonin, neurotransmitters norepinephrine and dopamine to the brain. MAOIs avoid this from happening which makes more of these brain chemicals obtainable to effect alterations in together cells and circuits that have been obstructed by depression.

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