An organism acquires a mutation in the gene for pyruvate dehydrogenase that renders the protein unable to bind nadh. what is the most likely consequence of this mutation?

The most likely consequence of the mutation is that ATP synthesis will proceed at a high rate even when the cell has an ample supply. In addition, enzyme is controlled by ATP levels since if ATP levels are high it is significant to openly prevent the reaction that obligates the substrate to glycolysis to permit the substrate to be obtainable for additional reactions ever since the cell has ample energy. 

The most likely consequence of this mutation, when an organism acquires a mutation in the gene for pyruvate dehydrogenase that renders the protein unable to bing nadh, is ATP synthesis will proceed at a high rate even when the cell has an ample supply.