1.
(ENZYME) recognizes start of a gene and begins to
the segment of DNA.

RNA polymerase recognizes start of a gene and begins to catalyze the segment of DNA

Explanation:

To start transcribing a gene, RNA polymerase attaches to the gene's DNA at a region known as the promoter. The promoter basically instructs the polymerase where to "sit down" on the DNA and start transcribing

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme