Bacteria such as e. coli and salmonella produce invasins that bind host cells, thus causing the cells to:

kill cells and tissues outright

Explanation:

Sometimes bacteria multiply so rapidly they crowd out host tissues and disrupt normal function. Sometimes they kill cells and tissues outright. Sometimes they make toxins that can paralyze, destroy cells' metabolic machinery, or precipitate a massive immune reaction that is itself toxic

Acrroding to http://needtoknow.nas.edu/id/infection/how-pathogens-make-us-sick/

as the gila monster consumes the eggs or young of the desert cottontail and gambel's quail, thus its main food supply is only accessible for a restricted time duration every year. however, for this, the gila monsters exhibit three adaptations, which elevate their survival rate in the desert condition.  

first, is that they possess huge bodies, and can consume greater concentrations of food during a small period. secondly, they require to feed infrequently as they can accumulate fat in their tails. ultimately, their rate of metabolism is very low, so that they can burn their reservoirs of fat gradually.