Which of the following tools was responsible for advancing our knowledge of cells over the past 400 years?

This is life science right? If it is the answer is the microscope

Explanation:

characterization of nanoparticles is a critical step in nanomaterial production as it provides information of dimension, morphology, surface charge, distribution and degree of surface functionalization.

lysosomes contain a variety of enzymes, enabling the cell to break down various biomolecules it engulfs, including peptides, nucleic acids, carbohydrates, and lipids (lysosomal lipase). the enzymes responsible for this hydrolysis require an acidic environment for optimal activity. hope i !