Which statement about the binding of enzymes and substrates is correct? Image displays enzyme substrate complex. The image on the left displays the two substrates. The image on the right displays the enzyme and substrate complex.

Substrate molecules bind to the active site of the enzyme only by weak bonds, such as hydrogen bonds or hydrophobic attraction.
When substrate molecules bind to the active site of the enzyme, the enzyme undergoes a slight change in shape.
When substrate molecules bind to the active site of the enzyme, the pH and temperature of the enzyme will change.
Substrate molecules fit into the active site of an enzyme like a key fits into a lock.