How does the change in structure between the different layers of the skin correlate with the change in function of the cells?

What was dr. willem johan kolff’s first step in using the scientific process to invent the hemodialysis machine? he built the machine and tried it with various patients, collecting data about its effectiveness. when a patient’s kidneys failed, he wondered if it would be possible to perform kidney functions with an external machine. he researched and collected data about numerous patients who exhibited symptoms of kidney failure. he drew conclusions from studies of various symptoms of kidney failure, and drew a design for the ideal external blood-processing machine.