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In addition to the three common alleles of gene I, the ABO blood type is controlled by a second gene, gene H. Individuals with at least one copy of the wild-type H allele produce substance H, a sugar polymer, on the surface of their red blood cells. Substance H is the precursor molecule to which the A and B polysaccharides are attached by the products of gene I. Individuals with the genotype hh do not have Substance H on their red blood cells, and so even if they have an IA or IB allele, the A and B polysaccharides cannot be attached to the red blood cell surface. Therefore, hh individuals appear to have blood type O regardless of their gene I alleles. This phenomenon, called the Bombay phenotype, can result in surprising pedigrees like the one shown. Examine this pedigree, then classify each statement as either true or false.
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In addition to the three common alleles of gene I, the ABO blood type is controlled by a second gene...
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