Alkaptoneuria is a recessive genetic disorder found among North American populations at a frequency of about 1 in 500,000 births. How frequently would you expect this defect to be expressed among children of second cousin marriages

The correct answer is - 1/41,493

Explanation:

Let assume the frequency of the two possible same allele genotype (dominant and recessive) in an inbred population is p and q. Then the frequency of heterozygotes (H) is denoted as:

2pq + 2pqF.  ( where F is the inbreeding coefficient).

The frequency of the two different hoozygotes in inbred population can be calculated as:

p2 + pqF and q2 + pqF. (Where p and q are the allele frequency of the dominant and recessive phenotype.

Given: Frequency of Alkaptonuria (q 2) = 1:500, 000

=> q = 1/707

p = 706/707 ( Approx values)

solution:

Inbreeding coefficient (F) = 1/64

Therefore,

Frequency of Alkaptonuria in second cousins= q 2 + pqF

= 1/500, 000 + (706/707 x 1/707) x (1/64)

= 1/500, 000 + 1/45, 248

= 1/41,493 (approx)

rain is the best answer

photosynthesis makes the glucose that is used in cellular respiration to make atp. the glucose is then turned back into carbon dioxide, which is used in photosynthesis. while water is broken down to form oxygen during photosynthesis, in cellular respiration oxygen is combined with hydrogen to form water.