It was found that the C4 protein promotes synaptic pruning during brain development in the teenage years. This is a normal process in brain development that is important for removing unnecessary connections between neurons and establishing a mature brain structure. However, high expression levels of a certain allele of C4 can lead to too much pruning, which may promote the onset of schizophrenia. The variation observed at the C4 gene which leads to the greatest increase in risk was found to cause a 25% increase in the risk of developing schizophrenia. The baseline risk in the population is 1%. What is the risk of an individual with this variant developing the condition?a. 0.25%. b. 1.25%.
c. 25%.
d. 26%.

b. 1.25%

Explanation:

Variations observed in C gene has increase in risk of 25% to develop schizophrenia. It is a kind of an abnormality in which a person interprets reality unrepresentative. The baseline risk in population is 1% then there is 1.25% risk associated with an individual to develop this condition.

an individual’s sex (i.e., whether they are a male or female) is determined by the sex chromosomes. most people have two sex chromosomes, one that is inherited from their mother and one that is inherited from their father. typically, females have two x chromosomes (xx) and males have one x chromosome and one y chromosome (xy). conditions caused by changes (“mutations”) in genes located on the x chromosome are considered x-linked.

x-linked recessive inheritance

most x-linked conditions are recessive. this means that in a person with two x chromosomes (most females), both copies of a gene (i.e., one on each x chromosome) must have a change or mutation whereas in a person with one x chromosome (most males), only one copy of a gene must have a mutation. a female with a mutation in one copy of a gene on the x chromosome is said to be a “carrier” for an x-linked condition. a male with a mutation in a gene on the x chromosome is typically affected with the condition. because females have two copies of the x chromosome and males have only one x chromosome, x-linked recessive diseases are more common among males than females. however, x-linked recessive diseases can occur in both males and females.

for x-linked recessive disorders, an unaffected carrier mother who has a mutation in a gene on the x chromosome can transmit either the x chromosome with this mutation or a “normal” x chromosome to her children. if the father is unaffected, none of her daughters will be affected and all of her daughters will be unaffected—since they will inherit at least one normal x chromosome from their father. however, each daughter will have a 50% chance of being an unaffected carrier like her mother and a 50% chance of both x chromosomes being normal.

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