Please help,, which type of mutation will cause the most change to the organisms trait?

Framshift mutation

Explanation: A frameshift mutation has more effect because after it, all amino acids are altered. Usually, a frameshift mutation results in the synthesis of a nonfunctional protein.

the cladogram shown here shows similarities and differences among several classes of vertebrates. anatomically, the four have limb structure as their common ancestor. we might separate the mammals from the other three classes because they a) divergent; do not lay eggs b) identical; are warm-blooded c) varied; a four chambered heart d) homologous; have mammary glands