What are the applications of IGF1R Gene Editing?
IGF1R is a hetero-tetrameric protein with two identical extracellular α-subunits and two transmembrane ÎČ-subunits. The extracellular domain contains a cysteine-rich IGF-binding site. The transmembrane domain contains tyrosine kinase activity which depends on an ATP-binding site (lys1003) and a cluster of three tyrosine residues at positions 1131, 1135, and 1136. Activation of IGF1R initiates a cascade of downstream signaling pathways
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What are the applications of IGF1R Gene Editing?
IGF1R is a hetero-tetrameric protein with two iden...
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