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In areas of Africa where malaria is prevalent the number of sickle cell cases remains consistent generation after generation. support the hypothesis.

In Canada the incident of sickle cell anemia has been increasing in the population.  contradicts the hypothesis.

Explanation:

In areas of Africa where malaria is widespread the number of sickle cell cases remains consistent generation after generation while on the other hand, In Canada the incident of sickle cell anemia are lower in the population because of environmental condition is not good for increase in malarial disease. In Africa, the environment is suitable for the mosquitoes that causes malaria so there is high increase of sickle cell anemia in the population.