Which of these mutations do you think would have the worst effect on the function of the protein?
an insertion or
deletion near
the end of a
gene
an insertion or
deletion at the
beginning of
an insertion at
the middle of
a nonsense
mutation at the
end of the gene
a missense
mutation
the gene
the gene

Both are harmful for the organism in case of point mutation. In case of deletion or insertion of a particular fragment of the gene, deletion could be more harmful than insertion, because the deleted fragment of the gene will never be replaced at exact size and exact position of the disabled gene.

Explanation:

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