Name the organ systems that come in contact with the external environment

The answer for this question would be Integument, digestive, respiratory and urogenital.
The largest system that contact with the external environment would be integument and digestive. That makes two system has normal flora of microbes and not sterile like the other systems. Normal flora of microbes will prevent the pathogen microbe grows so it gives some benefit. 

Number one is sinkholes may form from water erosion