Budding yeast cells that are deficient for mad2, a component of the metaphase checkpoint, are killed by treatment with benomyl, which causes microtubules to depolymerize. in the absence of benomyl, however, the cells are perfectly viable. explain why mad2-deficient cells live in the absence of benomyl but die in its presence.

Without benomyl, the larger part of axles shape ordinarily and the axle connection checkpoint assumes no part. As a result, Mad2 is immaterial. Within the sight of benomyl, notwithstanding, cells that are damaged for Mad2 can't stop cell-cycle movement, with the outcome that chromosomes are isolated erroneously, making the cells pass on.