Which of the following affect(s) the distribution of a drug?
a. the rate of metabolism
b. excretory functions
c. the functioning of the liver and kidneys
d. fat solubility and protein-binding ability

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme

maritime tropical may be your answer.

yes, because even though a theory has a  lot of evidence to support it, it is not always true