According to the hardy-weinberg principle, which of the following is most likely to disrupt genetic equilibrium

Answer - There can be many factors such as mutations, natural selection, nonrandom mating, genetic drift, gene flow. But nonrandom mating can have long term effects.

Reason - Reason why it has a long term effect is because of the survival of that organisms and how it will adapt to its own environment with the introduction of nonrandom mating etc..

What's the question?

The first means of speeding up reactions mentioned by the speaker is raising the enzymes