Which of the following describe(s) the role of cytotoxic t cells in the specific immune response?
i. they kill cancer cells.
ii. they kill cells infected by viruses.
iii. they interact with mhc-i molecules
a. ii only
b. ii and iii only
c. i and ii only
d. i and iii only
e. i, ii, and iii

Option E is the correct answer

Explanation:

T cells are part of the adaptive immune system and have a large repertoire of receptors that allow their activation or inhibition. T lymphocytes or T cells have the ability to recognize and lyse (kill) infected or transformed cells; these transform cells could include cancer or tumor cells. This recognition is due to the contact of the T cell receptors (principally the T cell receptor) with the Major Histocompatibility Complex molecule I (also known as MHC I). When cells are infected or are transformed, the expression of these MHC I molecules are altered, and therefore it is detected by T cells as something “abnormal” and therefore release molecules that cause cell death, such as perforin, granzymes, IFN-γ and the Tumor Necrosis Factor-α. Therefore, T cells can kill cancer or infected cells and interact with MHC-I molecules.

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