Please help! Which of the following statements about chromatin is true?
Multiple choice
1. Nucleosomes that are acetylated are associated with DNA that is inaccessible to RNA polymerase and other transcription factors
2. Chromatin in an open conformation is bound to many nucleosomes.
3. Covalent modification of histone tails always leads to an increase
transcription.
4. Covalent modification of histone talis always leads to a decrease in transcription.
5. Modifying the accessibility of chromatin leads to complex regulation of eukaryotic gene expression.