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HIV replication requires conversion of the genomic RNA present in the infecting virus to a double stranded DNA that integrates into a human chromosome. Unlike DNA polymerase, HIV reverse transcriptase catalyzes DNA chain elongation from either a DNA or RNA template. Azidothymidine (AZT) was the first effective drug used to inhibit HIV reverse transcriptase and went into clinical use in 1987 to treat AIDS. What best describes how AZT inhibits reverse transcriptase
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