The trait for hemophilia is sex-linked (on the X chromosome) and recessive. If a female who is a carrier of hemophilia (XHXh) mates with a man with normal blood (XHY):What are the
chances of their daughters having hemophilia? What are the chances of their sons having
hemophilia?

If the mother is a carrier and the father is normal, the outcomes for potential children would be:

XH Xh
XH XHXH XHXh
Y XHY XhY

So let’s break these down
XHXH = will be a daughter (XX) with normal blood (HH)
XHXh = will be a daughter (XX) who is a carrier for hemophilia (Hh)
XHY = will be a son (XY) with normal blood (H)
XhY = will be a son (XY) with hemophilia (h)

Because this disease is inherited on the X chromosome, male offspring tend to either have it or not. They can’t be carriers because they only have one X chromosome. So the chances of having a son with hemophilia will be 50% cause the boys have a 50% chance of inheriting hemophilia.

On the other hand, daughters will either have normal blood or be carriers in this situation. So to answer the question, the chance a daughter of this couple would have of inheriting hemophilia is 0%. This only changes if their father has hemophilia. Then they will either be a carrier or will have hemophilia.

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