Huntington's Disease (HD) is a rare and fatal neurodegenerative disorder that results in hyperkinesia. One of the issues that occurs as a result of Huntington's is deficits in axonal transport mutations in the huntingtin (Htt) gene result in the loss of anterograde transport of organelles such as mitochondria. Among their many functions, mitochondria are thought to sequester Ca ions. 2 You are working with an animal model of HD. You are recording postsynaptic responses of neurons receiving synaptic inputs from presynaptic neurons in either normal tissue or HD tissue. You note that the postsynaptic responses occur 3-5x more often in the HD tissue than that of normal tissue. Propose a mechanism wherein the Ht mutation could produce this increase in the responses of the HD neurons.
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Huntington's Disease (HD) is a rare and fatal neurodegenerative disorder that results in hyperkinesi...
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