PLEASEEE HEL TIMES TEST !! Aminoacyl-tRNA synthetase is an enzyme that is responsible for attaching the correct amino acid to the tRNA
molecule. As the mRNA transcript is read by the ribosome, the complementary tRNA molecule then brings the correct
amino acid to the polypeptide chain. Although aminoacyl-tRNA synthetase is very accurate, it will rarely attach the
wrong amino acid to the tRNA. Which of the following could be the cause of an error in this process that results in the
histidine amino acid being substituted for a phenylalanine amino acid, causing a misfolding of polypeptide chain?
O The wobble effect of tRNA will allow aminoacyl-tRNA synthetase to bind to a group of amino acids.
O Aminoacyl-tRNA synthetase will change the structure of the tRNA to allow for binding to a different amino acid.
O Certain amino acids have very similar structures in their attachment ends and can cause aminoacyl-tRNA
synthetase to bind to the wrong amino acid.
O Aminoacyl-tRNA synthetase determines if a misreading error has occurred by the ribosome and will replace the
tRNA anticodon to pair with a different amino acid.