To stop a wound from bleeding, platelets in the blood clump together to form a blood clot. The clot dries into a hard scab to protect the wounded area. Underneath the scab, the blood supplies nutrients and oxygen that help new skin cells form. As the skin regenerates, the wound closes. Which body systems interact with the integumentary system to close the wound?

A. Circulatory and reproductive

B. Immune and circulatory

C. Reproductive and immune

D. Digestive and endocrine