Breaking down of ATP or of the ATP returns the myosin molecule to the high energy conformation.

Hydrolysis

Explanation:

Actin is a protein that forms thin filaments which are part of the contractile apparatus in muscle cells. In these cells contraction is triggered by the interaction between actin filaments and myosin filaments that produces their movement relative to one another, a process that requires adenosine triphosphate (ATP). In the first place, myosin-ATP binding causes myosin heads to release actin. Subsequently, ATP hydrolysis induces a conformational change in the myosin filament, thereby myosin 'walks on the actin filament' as the muscle is contracted. After ATP hydrolysis, myosin filaments return to its high-energy configuration.

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