What would happen if the 9th letter in your DNA strand switched from a T to a G

Protein synthesis errors can also produce polypeptides that show the benefit of toxic activity. In rare cases, the defect may provide a different or pathological function to a normally wrapped protein. Often, errors disrupt the fold, and a well-threatened molecule can be toxic. Perhaps the protein will not be made or made improperly. When mutations occur in gametes, the DNA of the offspring will be positively, negatively, or neutral.

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the denominator has a very specific role.