The lac operon is regulated by both the availability of lactose and glucose. How does E. coli regulate transcription of the lac operon?

E. coli regulate transcription of the lac Operon through the production of a small molecule called cyclic AMP (cAMP).

Explanation:

The lac operon is regulated by both the availability of lactose and glucose. E. coli regulate transcription of the lac Operon through the production of a small molecule called cyclic AMP (cAMP).

This cAMP acts a signaling agent which is made by E. coli anytime glucose levels are low In the cells which helps regulate the transcription process as glucose is needed for it .