Directions: Identify which source of genetic variation led to the mutations described in the scenario. Support the response with citations from the passage and the text in CER format. Support your response with evidence from the passage and reasoning as to why that evidence supports your claim. Scenario:

A couple had a child who they discover has a heart defect that will limit what the child can do when they get older. They will never be able to participate in sports or other strenuous activities for fear that the child’s heart will develop an uneven rhythm and stop functioning. The mother of the child is the oldest of 7 children and the first to have a child. She is concerned that the heart condition may be occur in the children of her siblings if they reproduce. The father of the child is an only child but likewise wishes to know how this has happened since there he has no family history of the disorder on his side. Both sets of grandparents are living and everyone visits a genetic specialist to have their genomes compared to that of the child with the heart condition. What the specialist finds is that there is no evidence of the heart condition in either the parent’s or the grandparent’s genome. An interview with both of the parents reveals that neither of them have ever been smokers, exposed to radiation, or contracted viruses which could cause this disorder. The family and the specialist are stumped and need assistance in finding how the child developed this heart condition.

Claim:

Evidence:

Reasoning: