What is a difference between prokaryotes and eukaryotes cells

The main difference between eukaryotic and prokaryotic cells is defined by the presence of true nucleus and most organelles in the eukaryotic cell, which do not possess prokaryotes.

Explanation:

Cells are the simplest expression of living beings —the structural and functional unit— and are classified, according to their complexity, into prokaryotic and eukaryotic cells.

Prokaryotic cells are simple cells that lack a nucleus -so their genetic material is dispersed in the cytoplasm- and most of the organelles. This cell type is unable to become a specialized cell or to group together to form tissues, so it is only found in single-cell organisms, such as bacteria.

On the other hand, eukaryotic cells have a true nucleus —where DNA is found— all organelles, can differentiate and group together to form tissues. This latter property makes them suitable for forming multicellular organisms.

yes it is weird but true