Sickle cell anemia is a genetic condition that occurs because of a single point mutation in the DNA gene for hemoglobin. How is this mutation expressed in humans?

Hello. Let me explain.

Explanation:

This type of anemia first of all before the Erytrocyte loses its nucleus ،at chromosome number 11 this mutation happens and valine (s type of amino acid)is replaced with glutamic acid.

Then this abnormal hemoglobins are produced in ribosomes (after transcription and translation).

This hemoglobins make a long strand which makes the RBC have a sickle shape.

This abnormal cells are very fragile.

The normal RBC is alive for about 120 days but this cells are slive for just 15 days.

This sickle shaped cells can also close blood vessels.

Macrophages destroy them so the anemia accurs.

idk why hjggjhjkhj

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