An elevation of purine nucleotides will negatively regulate pyrimidine synthesis through which of the following mechanisms? a. Inhibiting the activity of carbamoyl phosphate synthetase II
b. Increasing degradation of pyrimidine bases
c. Increasing the activity of the non-oxidative reactions of the pentose pathway
d. Inhibiting the activity of thymidylate synthase

a.

Explanation:

It will do this through the mechanism of Inhibiting the activity of carbamoyl phosphate synthetase II . This is because carbamoyl phosphate synthetase is the regulatory enzyme for pyrimidine synthesis. Alone carbomyl phosphate synthetase is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol.

a unit of heredity that is transferred from a parent to offspring and is held to determine some characteristic of the offspring.