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You want to look at the connection between ribonucleotide reductase and thymidylate synthase. You carry out an in vitro experiment (in a test tube) with wild-type ribonucleotide reductase and thymidylate synthase along with any additional enzymes needed. You also include in the test tube ribonucleotides (ATP, CDP, UDP, GDP, and ADP), 7,8-dihydrofolate, NADPH, serine, and an inhibitor of thymidylate synthase. List the diphosphate deoxyribonucleotides that will be produced as a result of this in vitro experiment. Discuss the effects of inhibiting the thymidylate synthase on the activity of the ribonucleotide reductase.
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