Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach? A) oncogenes
B) proteins with loss-of-function mutations
C) proteins with gain-of-function mutations
D) tumor suppressor genes

C) proteins with gain-of-function mutations

Explanation:

Gain-of-function mutations: In biology, the term "gain-of-function mutation" is described as one of the different types of mutation in which the altered or changed "gene product" consists of an entirely new pattern or molecular function associated with gene expression. However, the "gene-of-function mutations" are being always considered as "Semidominant or Dominant".

In the question above, the correct answer is option C.

1: the largest region of the brain is the:

  cerebrum

2. the term "psychology" literally means:

the process or procedure of the science or study of the mind.

3. the area of the brain responsible for respiration, heart rate, and smooth muscle control of our blood vessels is t

medulla oblongata

4. the structure that conducts nerve impulses to and from the brain and serves as a reflex center for some sensory information without input from the brain is the:

spinal cord

5. the three-layered membrane that covers the brain and spinal cord and literally means membrane is called the:

meninges

6. the cord-like (string-like) structures that carry bio-electrical impulses from one part of the body to another are called

nerves

7. a group of nerve cell bodies that are found outside of the spinal cord and brain are referred to as:

ganglions or ganglia (pl.) “literal meaning knot”

8. the term that means spinal cord inflammation is:

myel/itis