What are two factors that can affect an enzyme from working or become denatured

The activity of an Enzyme is affected by its environmental conditions. Changing these alter the rate of reaction caused by the enzyme. In nature organisms adjust the conditions of their enzymes to produce an Optimum rate of reaction where necessary or they may have enzymes which are adapted to function well in extreme conditions where they live.

I’m not really sure

Ithink the answer is d.