Keith and Marsha's only child to have a carrier genotype, Jeff, did marry. Cedric remained single due to poor health, and Nita swore off marriage after several bad relationships. Jeff and his wife Adrienne had four children, Angela, Keith, Joyce, and Denise. Although the parents were not expecting it to happen, their only son and their second born girl were born with sickle cell disease. Post- pedigree questions: If you were Ketih and Marsha's genetic counselor, what would you tell them? Which of the Jackson's grandchildren are definitely carriers? What is Adrienne's genotype?