Nancy suffer from insulin dependent diabetes mellitus and is on insulin therapy. You administered her insulin dose orally and realized hours that she still hyperglycaemic despite your administration of the right dose. Explain what might have led to this?

 Insulin is a hormone, which is secreted by the pancreas to regulate the sugar levels in the bloodstream.

Explanation:

Insulin is a protein hormone if take orally, will get digested in the digestive tract, it will not be able to affect the target site of action.

Insulin gets denatured in the digestive tract. Thus it will not be able to control the blood sugar levels.

Nancy has taken the insulin dose orally, the insulin will get denatured in the digestive system, it will not function and Nancy will remain hyperglycemic after the consumption.