Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?Choose one or more:
A.) oncogenes
B.) proteins with loss-of-function mutations
C.) proteins with gain-of-function mutations
D.) tumor suppressor genes
Answers: 1
Biology, 21.06.2019 19:00
One statements is an example of a scientific observation. another statement is an example of a scientific explanation. identify the correct statement for each category to illustrate how scientific explanations are inferred from scientific observations.
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Biology, 22.06.2019 20:30
The hershey and chase experiments involved the preparation of two different types of radioactively labeled phage. which of the following best explains why two preparations were required? a. the bacteriophage used in the experiments was a t2 phage. b. it was necessary that each of the two phage components, dna and protein, be identifiable upon recovery at the end of the experiment. c. each scientist had his own method for labeling phage, so each conducted the same experiment using a different isotope. d. establishing the identity of the genetic material required observation of two phage generations.
Answers: 2
Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the pr...
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