A yeast strain has a temperature sensitive mutation in the SRP receptor. At low temperatures, the SRP receptor functions normally. At elevated temperatures, the SRP receptor is marked for proteolytic destruction. If you shifted a culture of this yeast strain to elevated temperatures, what would be the immediate impact on proteins that are normally co-translationally inserted into ER?

Immediate observation would be denatured proteins

Explanation:

Proteins gain their structural integrity from their tertiary structure. There are some structural amino acids such as proline that provide a rigidity to proteins that allow it to maintain it's shape through various biotic and abiotic changes.

In heat sensitive mutations the protein sequences that are responsible for structural maintenance are lost or compromised. This causes immediate loss of function once the protein is outside of it's ideal environment.  

hormones in blood stream

image: dtc.ucsf.edu

endocrine glands secrete hormones into the blood stream near them; the hormones then travel in our bloodstream until it reaches its destination, called a target cell, in distance parts of the body. in the target tissue, hormones lock onto the target’s plasma membrane, called the receptor site.

transcription is a process in which information is rewritten. it is something our cells must do, in a more specialized and narrowly defined way. in biology, transcription is the process of copying out the dna sequence of a gene in the similar alphabet of rna. it needs to happen in the nucleus because that's where the dna is. dna is always inside the nucleus unless the cell is dividing.

transcription is the first step in gene expression, which involves copying a gene's dna sequence to make an rna molecule. transcription is performed by rna polymerases. it has three stages: initiation, elongation, and termination. rna molecules must be processed after transcription in eukaryotes.

explanation:

long version:

the protein synthesis consists two processes which are, transcription and translation. transcription takes place in the nucleus. it uses dna as a template to make an rna molecule. rna then leaves the nucleus and goes to a ribosome in the cytoplasm, where translation occurs. transcription is the first part of the central dogma of molecular biology: dna → rna. it is the transfer of genetic instructions in dna to messenger rna (mrna). during transcription, a strand of mrna is made that is complementary to a strand of dna.  

these three stages are:

  initiation: in which   is the beginning of transcription.occuring when the enzyme rna polymerase binds to a region of a gene called the promoter. this signals the dna to unwind so the enzyme can ‘‘read’’ the bases in one of the dna strands. the enzyme is now ready to make a strand of mrna with a complementary sequence of bases.

    elongation: in which is the addition of nucleotides to the mrna strand. rna polymerase reads the unwound dna strand and builds the mrna molecule, using complementary base pairs. there is a brief time during this process when the newly formed rna is bound to the unwound dna. during this process, an adenine (a) in the dna binds to an uracil (u) in the rna.

    termination: in which is the ending of transcription, and occurs when rna polymerase crosses a stop (termination) sequence in the gene. the mrna strand is complete, and it detaches from dna.