Which one of the following is TRUE? Enzymes work generally on a broad range of substrates. Enzymes are used up in chemical reactions. An enzyme's function depends on its three-dimensional shape. Enzymes emerge changed from the reactions they catalyze.

During crossing-over, a. genetic material is exchanged between nonsister chromatids, resulting in new combinations of alleles. b. nonsister chromatids from each homologous chromosome of a tetrad are exchanged, resulting in new combinations of alleles. c. one homologous chromosome of a tetrad is exchanged with another tetrad, resulting in new combinations of alleles. d. sister chromatids from each homologous chromosome of a tetrad are exchanged, resulting in new combinations of alleles. e. genetic material is exchanged between sister chromatids, resulting in new combinations of alleles.