When both glucose and lactose are present in the growth medium, E. coli cells preferentially use glucose as an energy course for all of these reasons, EXCEPT: Group of answer choices Glucose can enter glycolysis directly. Lactose cannot diffuse across the cell membrane without a transporter. Glucose accumulation negatively regulates the activity of a Lac operon activator. Lactose cannot enter glycolysis directly. Lactose is a catabolite of glucose metabolism.