Indicate whether each of the following conditions would increase or decrease the effect of acetylcholine. A. addition of a drug that stimulates the GTPase activity of the Gα subunit B. mutations in the K+ channel that keep it closed all the time C. modification of the Gα subunit by cholera toxin D. a mutation that decreases the affinity of the βγ complex of the G protein for the K+ channel E. a mutation in the acetylcholine receptor that prevents its localization on the cell surface F. adding acetylcholinesterase to the external environment of the cell

Explanation:

Acetylcholine is a neurotransmitter, an organic chemical that that functions in the body and brain.

It is one of the substance released by the nerve cell, so that it can send signal to cells such as;gland cell, muscle cell. Acetylcholine causes contraction of muscles and also regulates endocrine functions. Lack of acetylcholine in the body can results to muscle weakness.(myasthenia)

To Indicate whether each of the below conditions would increase or decrease the effect of acetylcholine.

A.) addition of a drug that stimulates the GTPase activity of the Gα subunit.

INCREASE

B.) mutations in the K+ channel that keep it closed all the time.

DECREASE

C.) modification of the Gα subunit by cholera toxin

INCREASE

The reason is because Toxin inhibit GTP hydrolysis

D.) a mutation that decreases the affinity of the βγ complex of the G protein for the K+ channel.

DECREASE

E.) a mutation in the acetylcholine receptor that prevents its localization on the cell surface

DECREASE

.

F.) adding acetylcholinesterase to the external environment of the cell

DECREASE

.