Explain how it would be possible to have a change in a single base of DNA, but have the protein NOT change and be functional.

A silent mutation is a type of mutation that causes a change in a sequence of DNA nucleotide but do not affect the amino acid sequence or protein function.

Therefore, a silent mutation in the DNA sequence will not affect amino acids and proteins.

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Silent mutation will cause no change in amino acid sequence of the protein polypeptide chain hence no change in function of protein. Base pair change will still from the same amino acid.

Explanation:

When a single base of DNA or nucleotide gets change with no affect on the amino acid formed it is termed silent mutation.

In silent mutation, if a nucleotide gets change due to mutation the amino acid formed in translation would be same. This happens because substitution of base or new base codes for the same amino acid.

example in codon AAA if 3rd A gets change to G due to mutation and become AUG. Both these codons code for lysine.

Thus when amino acid is not changed the polypeptide will not change hence no confirmational or functional change in the protein.

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