Please choose whether you AGREE or DISAGREE with the following statement, and provide your reasoning:
"Switching the flanking charges around transmembrane domain 1 will flip the orientation of this protein in the plasma membrane." (In other words, if the N-terminal domain was originally in the cytoplasm, it will now be in the extracellular space. Or if the N-terminal domain was originally in the extracellular space, it will now be in the cytoplasm.)

segmentation=endoskeleton=backbone=coelom=tissues

as the gila monster consumes the eggs or young of the desert cottontail and gambel's quail, thus its main food supply is only accessible for a restricted time duration every year. however, for this, the gila monsters exhibit three adaptations, which elevate their survival rate in the desert condition.  

first, is that they possess huge bodies, and can consume greater concentrations of food during a small period. secondly, they require to feed infrequently as they can accumulate fat in their tails. ultimately, their rate of metabolism is very low, so that they can burn their reservoirs of fat gradually.  

in 1859, charles darwin set out his theory of evolution by natural selection as an explanation for adaptation and speciation. he defined natural selection as the "principle by which each slight variation [of a trait], if useful, is preserved".