You have a dish of mammalian cells in culture that are all about to enter mitosis (it is a synchronously replicating culture of cells). You add to the dish a drug that is a potent inhibitor of RhoA activity. Two hours later you analyze your cells under the microscope. Which of the following best describes what you might observe?

A. All cells appear to be in telophase.
B. Around 50 % of the cells have undergone apoptosis.

Answer of the question is explaine dbelow.

Explanation:

Rho GTPases interact with a variety of effectors to control actin cytoskeleton

reorganization, cell shape, and cell polarity. RhoA regulates cell shape and adhesion by

the assembly of contractile actin microfilaments into stress fibres. Rho GTPases also

regulate proliferation and cell-cycle progression, especially GuS transition.

All the cells are about to enter mitosis means they cross GuS transition, a drug that is a

potent inhibitor of RhoA activity has no affect on the cell because these cells already in

G2 phase. So, all the cells appear to be in telophase.

So, the correct choice is A. all the cells appear to be in telophase.

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